Thesis on chalcones
A review on the major sources of chalcones and the main molecular events involved in the modes of action of these natural products is achieved. In order to examine the structure-activity relationship, a 3D QSAR analysis was carried out by comparative molecular field analysis CoMFA method on the selected chalcones.
Chalcone synthesis journal
Chalcones are multifunctional molecules, since one particular structure can show multiple biological activities. Based on this diversity of biological activities, this review provides a general overview of the origin, sources, and biological activities of chalcones, and a brief discussion on the most important molecular sites of action of these compounds in different organisms. J Plant Res. Chalcones and chalcone derivatives have a huge number of different biological activities, which are highly appreciated in many areas. The docking results also showed that the tyrosinase inhibition might be due to the metal chelating effect of thione functionality in compounds until Conclusions The synthesized compounds were characterized by TLC, melting point, IR spectroscopy, elemental analysis and mass spectroscopy. Overall, chalcones are highly phytotoxic molecules and the works performed resulted in very promising results, although further studies on the mode of action and the biological effects of chalcones in the field are necessary to make real the use of these secondary metabolites in pest control and weed management. Table 2: Physicochemical characterization data for synthesized compounds Table 3: Interpreted IR spectra data of synthesized compound Table 4: Mass spectra data of synthesized compound The Chalcone derivatives showed that the molecular ion peak that equivalent to the molecular weight of proposed compound. They also performed pharmacophore mapping analysis on chalcone derivatives and concluded that ring A containing hydrophobic group and ring B containing hydrogen bonding substitutents are better for antitubercular activity Yuh-Meei et al. Download File. In the final part of the thesis, a series of twenty four oxadiazole and triazolothiadiazole derivatives were synthesized and evaluated for their mushroom tyrosinase inhibitory activity. The IR peak at cm-1 indicates that the presence of C-H aromatic streching. Effects of root-applied naringenin and chalcone on the growth of annual plants. Here we emphasized the promising biological activities of chalcones as bactericides, insecticides, fungicides, anti-viral and plant growth regulators; although more investigations are needed to fully understand the molecular mechanisms involved. Nowadays, an emerging but every time more priority interest is focused on the role of natural compounds in crop development and protection.
Antitumor, anti-inflammatory, anti-diabetic, anti-bacteria, anti-fungal, and many other activities have been investigated for natural-producing compounds during the last years Verpoorte, ; Dewick, ; Prashar et al.
Abstract Chalcones, i.
During the last decades, numerous investigations were carried out on the pharmacological activities of naturally occurring and synthetic chalcones, i. Effects of organic herbicides on phototrophic microbial communities in freshwater ecosystems.
The chemical structures of some chalcones cited in the text with a potential use in agriculture and plant protection are shown in Table 1. During the last decades, large amounts of synthetic pesticides have been used mainly in intensive agriculture for crop protection in a non controlled-way. Stipulin, a prenylated chalcone from Dalbergia stipulacea. Regarding pest defense and weed control, the most interesting biological activities of chalcones are the bactericide, antifungal, antihelmintic, insecticidal, insect antifeedant, antiviral and phytotoxic activities. Genes Nutr. In the present investigation, we are attempted to synthesis some chalcone derivatives, which are biologically important. Phytotoxic potential of trans-chalcone on crop plants and model species.
In general, trans-chalcone acts as an inhibitor of photosystem II by inhibiting electron transport chain dynamics on Arabidopsis plants. Recrystallized the compound with ethanol and dried at room temperature.
Chalcone thesis pdf
Curr Medic Chem. During the last decades, numerous investigations were carried out on the pharmacological activities of naturally occurring and synthetic chalcones, i. Chalcones are multifunctional molecules, since one particular structure can show multiple biological activities. Natural products as sources for new mechanisms of herbicidal action. Chourasiya, I. Selective growth suppression of five annual plant species by chalcone and naringenin correlates with the total amount of 4-coumarate: coenzyme A ligase. Chalcone suppresses lignin biosynthesis in illuminated soybean cells. A chalcone and two related flavonoids released from alfalfa roots induce nod genes of Rhizobium meliloti. Regarding the use of natural products for weed management, it is important to select the compounds with the higher activity at the lower concentration. The hydroxyl group was involved in hydrogen bonding with the backbone amide of Methionine nitrogen atom with the calculated free binding energy of Overall, chalcones are highly phytotoxic molecules and the works performed resulted in very promising results, although further studies on the mode of action and the biological effects of chalcones in the field are necessary to make real the use of these secondary metabolites in pest control and weed management. However, in , Onyilagha and collaborators found higher antiviral activities after testing 21 chalcones. The structure of the synthesized compounds was confirmed by IR, Mass and elemental analysis.
In all cases the Ref. Diverse molecular targets for chalcones with varied bioactivities. The effectiveness of chalcones is enhanced by the presence of electron-withdrawing substituents in ring A and electron-withdrawing or electron-releasing substituents in ring B.
Phytochem Rev. They are present in numerous families of dicotyledonous plants, and in some monocotyledonous, pteridophytes and gymnosperms Iwashina,but are synthesized as major components in the families Asteraceae, Moraceae, Fabaceae and Aristolochiaceae. Pigment chalcones are particularly spread in the subtribe Coreopsidinae of Compositae, such as the genera Dahlia, Coreopsis or Cosmos and in Dianthus caryophyllus Caryophyllaceae Harborne,
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